https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52161 Wed 28 Feb 2024 11:00:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36271 Notamacropus eugenii), to investigate whether Lucrin Depot (AbbVie), a GnRH agonist microsphere preparation, could (1) inhibit follicular development and estrus in a cycle reactivated by removal of pouch young (RPY) and (2) facilitate a synchronous return to estrus. Our results show that females reactivated with bromocriptine and RPY in early seasonal quiescence (July 2015) were inhibited by Lucrin Depot (0.125-0.5 mg kg ^-1, n=9) and unlike control females (n=3), did not copulate before Day 32 RPY. During the next breeding season (February 2016), the return to estrus after RPY was not delayed in animals treated with Lucrin Depot (=0.20 mg kg ^-1; n=12), and copulation occurred in treated and control females within the expected natural period after RPY (Day 26-33 RPY). In the following breeding season (March 2017), estrus was delayed in animals treated with Lucrin Depot (1.25 mg kg ^-1) on either Day 0 (Group A, n=6) or Day 10 (Group B, n=6) after RPY compared to control females (n=6). Estrus was detected in Group A between 39 and 66 days (55 ± 4.8d) and in Group B between 43 and 71 days (55.2 ± 3.9d) after RPY. In contrast, all control females underwent estrus and copulated as expected by Day 30 RPY. We conclude Lucrin Depot can inhibit ovarian follicular activity after RPY but as a standalone treatment does not result in a highly synchronous return to estrus in the tammar wallaby.]]> Wed 18 Mar 2020 17:07:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49292 Wed 10 May 2023 13:41:04 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44935 Tue 25 Oct 2022 10:36:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35505 Tue 25 Jul 2023 09:29:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40880 Tue 19 Jul 2022 14:38:17 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33892 Tue 13 Jul 2021 14:52:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40069 3 mm; 14 ± 2.1 and 15.3 ± 2.1 follicles >3 mm in the CL-bearing ovary and contralateral ovary respectively. Similarly, females in the SOvn Group had 11.4 ± 2.4 and 17.4 ± 1.9 follicles >3 mm in each respective ovary. Uterine flushing and ovarian histology confirmed that females in LucrinþSOvn and SOvn Groups had not ovulated, but normal oocytes were present in the follicles. By comparison, the Control Group had ovulated with a single embryo being recovered from the uterus of 4 of 5 females. In contrast to all groups, females in the Lucrin Group showed follicular suppression (all follicles <1.5 mm) and an unstimulated reproductive tract. We conclude that a suppression plus stimulation regimen using Lucrin Depot followed by PMSG and hCG has the capacity to synchronise oestrus, and that 20 IU of PMSG stimulates the development of antral follicles >3 mm in both ovaries. However, a single 500 IU treatment of hCG on Day 23 RPY was not able to induce ovulation in the tammar wallaby.]]> Tue 05 Jul 2022 08:00:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50548 Tue 01 Aug 2023 10:55:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36197 Sminthopsis crassicaudata). Forty-eight randomly selected females were treated with 5 or 10 mgkg^-1 Lucrin Depot (n = 24 per dose). Eighteen females per treatment had their reproductive activity scored at 4, 8, 12 and 16 weeks using two ovarian (Graafian follicle and corpus luteum status) and two reproductive tract (uterine and vaginal muscularity and vascularity) parameters that formed a reproductive activity score. Six females per treatment were paired with a male at 4 weeks. Fertility was assessed between 8 and 16 weeks by pouch check, and thereafter by dissection. The effects of the 5 and 10 mgkg^-1 doses were statistically equivalent. Females showed suppression at 4-8 weeks, an increase in reproductive activity at 8-12 weeks and all were cycling normally at 16 weeks. Six pouch young were born at 12 weeks to two females treated with the 5 mgkg^-1 dose. Nine embryos were recovered at 16 weeks from two females treated with the 10 mgkg^-1 dose. In conclusion, Lucrin Depot can suppress breeding, and fertile mating can occur in subsequent cycles in the dunnart. There is potential for Lucrin Depot to be used as an assisted breeding tool, but it may need to be combined with ovarian stimulation treatment to achieve practical levels of synchronisation in the fat-tailed dunnart.]]> Thu 27 Feb 2020 13:33:34 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48415 Thu 16 Mar 2023 14:03:57 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40472 Thu 14 Jul 2022 08:35:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7721 Sat 24 Mar 2018 08:41:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7517 Sat 24 Mar 2018 08:38:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8052 Sat 24 Mar 2018 08:35:02 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7618 Sat 24 Mar 2018 08:34:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1076 Sat 24 Mar 2018 08:32:09 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1646 Sat 24 Mar 2018 08:30:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:199 Sat 24 Mar 2018 07:42:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49559 Mon 22 May 2023 09:13:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37903 Mon 21 Jun 2021 15:18:27 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35587 Mon 09 Sep 2019 10:25:46 AEST ]]>